I use liv52 through most of the year, on or off orals. I will also use milk thistle while on cycle, especially on orals, but to be honest, it's really hard to say just how much they help. If it does, its not a huge difference. i have gone entire cycles, in the past, not using "liver protection" and my values weren't too different, based off my labs. I say this becuase I feel that (and im certainly not pointing the finger at you, but want to say this for everyone reading!) that some guys think that they can run any oral or combo of orals for any length of time, and be just fine, simply because they mega dosed milk thistle. At the end of the day, dont count on milk thistle or live 52, but it isnt going to hurt. I wouldn't over think it. I'd personally just start at the begining of your cycle and run it through PCT. Not only can orals cause stress on the liver, injectables can too, to a lesser extent, especially faster acting injectables, from what I have been told by my Dr.
At the end of the day, as I've said before, doing blood work to check your liver. Liver enzymes will be elevated on cycle, but as long as they remain in a stable place and not progressively higher and higher, you are probably good