Yes, you could do that. It would be especially effective if you are training body parts around that time that you want to improve. In the past, I've used insulin 3x wk on days that I trained bady parts that I wanted to improve. It will help to shuttle more nutrients to storage, thus helping recovery and growth. I wouldn't expect to see any dramatic changes, using it on sat and sunday, but as long as you understand how it works and how to use it safely, it isn't going to hurt. I just don't think the effect is going to be dramatic, in any way. If you use it in the morning, then eat through the day and train in the afternoon, I'd expect to feel some fuller pumps. That may be the most noticable effect you get from it.