Anxiety is a possible side effect with EQ. I'd consider myself prone to anxiety, but even at high doses, I have not experienced it while using EQ. I do know guys that have though, and it seems to not be a problem for most, when staying at or below 600m plus wks, due to the long half life. 400mg, along with 500mg test e should be a good program. I would start the adex at half of what you are considering, .5mg EOD, and see how you respond. Even that may be high, depending on how sensitive you are to estrogen. Some may need .5mg ED, but for many, it would be over kill, assuming you are using high quality adex. If you are dieting, then maybe moving to ED will be acceptable, in order to control estrogen and stay tight, but if you are "bulking", you may want to deal with a little more fluid and use it to your advange, for increased recovery and strength.