The main benefit of gh is in its ability to help with fat loss and staying lean while eating more.We all want to get the most out of our GH because it’s so much of an investment but really, the most important thing to do is just take it, period. Lol. After all these years, using gh and helping clients use it, Pharma GH, UGL, etc, I don't see a huge difference in the timing. I have been told by a researcher in PEDs, that for a man looking to grow, the best time to take it is pre workout. Thats mostly what I stick to. If I am dieting, I use it AM fasted before cardio. If you would like you could try splitting it up. Assuming you train in the evening, 1 shot in the AM. 1 pre workout. For muscle growing purposes, we are mostly interested in the IGF which is going to build up over a longer period of using gh. The GH will come and go but it leaves you with higher IGF1 levels, which will be the same no matter how you break it up.  Exogenous Gh will not be effected my food and insulin levels. It is a drug being directly injected into your body and works regardless of insulin and blood sugar levels.If you are fasted, it may be better for fat loss when dieting down is your goal. Best of luck brother