i would start with a low dose. if its rated at 40mcg clen per 1cc, i would start with 1/2 cc and see how it goes from there. i would take it early in the day in case the stim effect keeps you up at night. make sure that you move the injections around. dont just inject into the same exact spot. you want to move them across the area that you plan to reduce, giving about a space of 2 inches from yesterdays injection. it is meant to be taken every day and is fine for your wife. she may find that she needs to start at even a lower dose than 1/2cc. better off to be safe than sorry