depending on the dose of HGH, it is normal to retain water when you first begin using it. over time, i've found that you get used to the dose and tend to hold less water. none the less, i feel that i always hold a little more while on it vs off of it. this would be my only consideration when it comes to high BP. make sure you keep a very close eye on your BP and if you need meds, be sure to use them. even slightly elevated BP can cause kidney problems over a number of years. if you dont have a cuff, get one. the regular cuff doesnt fit around the average BBers arm so you can find them for obese people. you can also use a wrist cuff, but they arent as accurate. the best thing you can do if you get that type, is to take it in to your MD and test it against thier machine, so you have a better idea of how far off it is.