The clen and yohimbine become systemic, effecting the whole body, just like if you were to take them orally, but Helios also has an ability to help burn fat locally. if you helios is dosed at 40mcg clen per 1cc, I would start with 1/2 cc ED and see how you respond to the side effects. After a wk, move to 1ccED. I would work up to taking no more than 2cc per day, running the total cyce for 8 wks