Hey bro, glad to hear that she is making progress. Over time, she will experience receptor down regulation, but it won't stop working. My suggestion was to start at 20mcg and increase by 20mcg every 2 wks. Each time you go up, it will start working strongly. Once she has built it up to a high dose, it will keep working through the duration of the remaining weeks, no problem. Over time, it won't be quite as effective as it once was, but it still will have its effect. IME, it's always been better to use it this way than 2 wks on, 2 off, as you often see on the net.