It is a very strong drug. It works well but you need to respect it. Everyone is different. I would start low, 250mcg a day for a week. Then consider going to 500mcg for 2 more wks if you find 250 ok. 750 is a high dose. I would not personally suggest it for an average guy. 500mcg is plenty. I would use it no longer than 3-4 wks at a time