Hey brother, As I am sure you know, tren is known for causing major side effects. Having run tren many times, I still start it  at 50mg EOD of tren ace. I prefer ace over E or Hex because of the shorter controllable ester and the ease in availability and cost over hex. If I were to run a 16 wk cycle, I would start with test e. cyp or sust and of course adex. Test dosing will depend on your experience. If you are still newer to cycling, 500mg test would be fine. If fat loss is my goal I would add clen in starting earlier. Then when I have about 10 to 12 wks left and I’m confident fat loss has already gotten on the right track, I add in the tren ace, as I mentioned, 50 EOD. Because I am doing EOD I would also then break my test into EOD shots to keep it all consistent from shot to shot. After 4 or so weeks, if the 50 is going well and you are tolerating sides, you can try to increase to 75 or even 100mg EOD.